A structural window into the evolution of secondary transport mechanisms

Abstract

Protein sequence signatures suggest that eons ago, a bacterial glutamate transporter lost its sodium coupling to make way for a shift to proton coupling. A study now maps this ancient transition in biochemical and structural detail to better understand how secondary transporters control their energetics.

Sam Berry

Postdoctoral Fellow

Postdoctoral fellow at the Wellcome Sanger Institute studying the mutational landscapes of proteins.